4ykb: Difference between revisions

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-'''Unreleased structure'''
-The entry 4ykb is ON HOLD  until Mar 04 2017
+==Structure of GUN4 from Chlamydomonas reinhardtii==
+<StructureSection load='4ykb' size='340' side='right'caption='[[4ykb]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ykb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YKB FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ykb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ykb OCA], [https://pdbe.org/4ykb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ykb RCSB], [https://www.ebi.ac.uk/pdbsum/4ykb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ykb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A8I5N5_CHLRE A8I5N5_CHLRE]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The genomes uncoupled 4 (GUN4) protein stimulates chlorophyll biosynthesis by increasing the activity of Mg-chelatase, the enzyme that inserts magnesium into protoporphyrin IX (PPIX) in the chlorophyll biosynthesis pathway. One of the roles of GUN4 is in binding PPIX and Mg-PPIX. In eukaryotes, GUN4 also participates in plastid-to-nucleus signalling, although the mechanism for this is unclear. Here, the first crystal structure of a eukaryotic GUN4, from Chlamydomonas reinhardtii, is presented. The structure is in broad agreement with those of previously solved cyanobacterial structures. Most interestingly, conformational divergence is restricted to several loops which cover the porphyrin-binding cleft. The conformational dynamics suggested by this ensemble of structures lend support to the understanding of how GUN4 binds PPIX or Mg-PPIX.
-Authors: Tabriz, S.T., Langley, D.B., Willows, R.D., Duff, A.P., Harrop, S.J.
+Structure of GUN4 from Chlamydomonas reinhardtii.,Tarahi Tabrizi S, Langley DB, Harrop SJ, Duff AP, Willows RD Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):1094-9. doi:, 10.1107/S2053230X15012248. Epub 2015 Jul 29. PMID:26249706<ref>PMID:26249706</ref>
-Description: Structure of GUN4 from Chlamydomonas reinhardtii
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Langley, D.B]]
+<div class="pdbe-citations 4ykb" style="background-color:#fffaf0;"></div>
-[[Category: Duff, A.P]]
+== References ==
-[[Category: Tabriz, S.T]]
+<references/>
-[[Category: Willows, R.D]]
+__TOC__
-[[Category: Harrop, S.J]]
+</StructureSection>
+[[Category: Chlamydomonas reinhardtii]]
+[[Category: Large Structures]]
+[[Category: Duff AP]]
+[[Category: Harrop SJ]]
+[[Category: Langley DB]]
+[[Category: Tabriz ST]]
+[[Category: Willows RD]]