4x7q: Difference between revisions

<StructureSection load='4x7q' size='340' side='right'caption='[[4x7q]], [[Resolution|resolution]] 2.33&Aring;' scene=''>

<table><tr><td colspan='2'>[[4x7q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X7Q FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3YR:2-(2,6-DIFLUOROPHENYL)-N-{4-[(3S)-PYRROLIDIN-3-YLOXY]PYRIDIN-3-YL}-1,3-THIAZOLE-4-CARBOXAMIDE'>3YR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7q OCA], [https://pdbe.org/4x7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x7q RCSB], [https://www.ebi.ac.uk/pdbsum/4x7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x7q ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PIM2_HUMAN PIM2_HUMAN] Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.<ref>PMID:18593906</ref> <ref>PMID:18675992</ref> <ref>PMID:20307683</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Marcotte DJ]]

[[Category: Silvian LF]]