4x6c: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4x6c]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X6C FirstGlance]. <br> | <table><tr><td colspan='2'>[[4x6c]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X6C FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=42H:(4R,7R,18Z)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOS-18-EN-1-AMINIUM+4-OXIDE'>42H</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=42H:(4R,7R,18Z)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOS-18-EN-1-AMINIUM+4-OXIDE'>42H</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x6c OCA], [https://pdbe.org/4x6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x6c RCSB], [https://www.ebi.ac.uk/pdbsum/4x6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x6c ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x6c OCA], [https://pdbe.org/4x6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x6c RCSB], [https://www.ebi.ac.uk/pdbsum/4x6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x6c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 10:41, 27 September 2023
CD1a ternary complex with lysophosphatidylcholine and BK6 TCRCD1a ternary complex with lysophosphatidylcholine and BK6 TCR
Structural highlights
FunctionCD1A_HUMAN Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.[1] [2] [3] Publication Abstract from PubMedA central paradigm in alphabeta T cell-mediated immunity is the simultaneous co-recognition of antigens and antigen-presenting molecules by the alphabeta T cell antigen receptor (TCR). CD1a presents a broad repertoire of lipid-based antigens. We found that a prototypical autoreactive TCR bound CD1a when it was presenting a series of permissive endogenous ligands, while other lipid ligands were nonpermissive to TCR binding. The structures of two TCR-CD1a-lipid complexes showed that the TCR docked over the A' roof of CD1a in a manner that precluded direct contact with permissive ligands. Nonpermissive ligands indirectly inhibited TCR binding by disrupting the TCR-CD1a contact zone. The exclusive recognition of CD1a by the TCR represents a previously unknown mechanism whereby alphabeta T cells indirectly sense self antigens that are bound to an antigen-presenting molecule. alphabeta T cell antigen receptor recognition of CD1a presenting self lipid ligands.,Birkinshaw RW, Pellicci DG, Cheng TY, Keller AN, Sandoval-Romero M, Gras S, de Jong A, Uldrich AP, Moody DB, Godfrey DI, Rossjohn J Nat Immunol. 2015 Mar;16(3):258-266. doi: 10.1038/ni.3098. Epub 2015 Feb 2. PMID:25642819[4] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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