4wmd: Difference between revisions

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OCA

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 ==Crystal structure of catalytically inactive MERS-CoV 3CL protease (C148A) in spacegroup C2221==
-<StructureSection load='4wmd' size='340' side='right' caption='[[4wmd]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
+<StructureSection load='4wmd' size='340' side='right'caption='[[4wmd]], [[Resolution|resolution]] 2.58&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4wmd]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WMD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WMD FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4wmd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WMD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WMD FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.585&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wme|4wme]], [[4wmf|4wmf]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wmd OCA], [http://pdbe.org/4wmd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wmd RCSB], [http://www.ebi.ac.uk/pdbsum/4wmd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wmd ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wmd OCA], [https://pdbe.org/4wmd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wmd RCSB], [https://www.ebi.ac.uk/pdbsum/4wmd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wmd ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/W6A941_MERS W6A941_MERS] Catalytic subunit of viral RNA capping enzyme which catalyzes the RNA guanylyltransferase reaction for genomic and sub-genomic RNAs. The kinase-like NiRAN domain of NSP12 transfers RNA to the amino terminus of NSP9, forming a covalent RNA-protein intermediate. Subsequently, the NiRAN domain transfers RNA to GDP, forming the core cap structure GpppA-RNA. The NSP14 and NSP16 methyltransferases then add methyl groups to form functional cap structures.[ARBA:ARBA00034461]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 19: @@
 </div>
 <div class="pdbe-citations 4wmd" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Virus protease 3D structures|Virus protease 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Lountos, G T]]
+[[Category: Large Structures]]
-[[Category: Needle, D]]
+[[Category: Middle East respiratory syndrome-related coronavirus]]
-[[Category: Waugh, D S]]
+[[Category: Lountos GT]]
-[[Category: 3cl protease]]
+[[Category: Needle D]]
-[[Category: Coronavirus]]
+[[Category: Waugh DS]]
-[[Category: Hydrolase]]
-[[Category: Mer]]