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==Crystal structure of lincosamide antibiotic adenylyltransferase LnuA, lincomycin-bound==
==Crystal structure of lincosamide antibiotic adenylyltransferase LnuA, lincomycin-bound==
<StructureSection load='4wh5' size='340' side='right' caption='[[4wh5]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='4wh5' size='340' side='right'caption='[[4wh5]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4wh5]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4e8j 4e8j]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WH5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4wh5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_haemolyticus Staphylococcus haemolyticus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4e8j 4e8j]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WH5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WH5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3QB:METHYL+(5R)-5-[(1R,2R)-2-HYDROXY-1-{[(4R)-1-METHYL-4-PROPYL-L-PROLYL]AMINO}PROPYL]-1-THIO-BETA-L-ARABINOPYRANOSIDE'>3QB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3QB:LINCOMYCIN'>3QB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4e8j|4e8j]], [[4fo1|4fo1]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wh5 OCA], [https://pdbe.org/4wh5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wh5 RCSB], [https://www.ebi.ac.uk/pdbsum/4wh5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wh5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wh5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wh5 RCSB], [http://www.ebi.ac.uk/pdbsum/4wh5 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LINA_STAHA LINA_STAHA]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Anderson, W F.]]
[[Category: Large Structures]]
[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
[[Category: Staphylococcus haemolyticus]]
[[Category: Courvalin, P.]]
[[Category: Anderson WF]]
[[Category: Dong, A.]]
[[Category: Courvalin P]]
[[Category: Egorova, O.]]
[[Category: Dong A]]
[[Category: Evdokimova, E.]]
[[Category: Egorova O]]
[[Category: Kudritska, M.]]
[[Category: Evdokimova E]]
[[Category: Minasov, G.]]
[[Category: Kudritska M]]
[[Category: Savchenko, A.]]
[[Category: Minasov G]]
[[Category: Stogios, P J.]]
[[Category: Savchenko A]]
[[Category: Yim, O.]]
[[Category: Stogios PJ]]
[[Category: Adenosine triphosphate]]
[[Category: Yim O]]
[[Category: Alpha+beta structure]]
[[Category: Aminoglycoside-2''-adenylyltransferase superfamily]]
[[Category: Antibiotic resistance]]
[[Category: Clindamycin]]
[[Category: Intracellular]]
[[Category: Lincomycin]]
[[Category: Lincosamide adenylyltransferase]]
[[Category: Lincosamide antibiotic]]
[[Category: Nucleotidyltransferase superfamily]]
[[Category: Structural genomic]]
[[Category: Transferase]]
[[Category: Transferase-antibiotic complex]]

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