4w5k: Difference between revisions

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 ==Structure of a mitochondrial aspartate aminotransferase from Trypanosoma brucei, K237A mutant==
-<StructureSection load='4w5k' size='340' side='right' caption='[[4w5k]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+<StructureSection load='4w5k' size='340' side='right'caption='[[4w5k]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4w5k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W5K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W5K FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4w5k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W5K FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eu1|4eu1]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_transaminase Aspartate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.1 2.6.1.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w5k OCA], [https://pdbe.org/4w5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w5k RCSB], [https://www.ebi.ac.uk/pdbsum/4w5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w5k ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w5k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4w5k RCSB], [http://www.ebi.ac.uk/pdbsum/4w5k PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q385Q9_TRYB2 Q385Q9_TRYB2]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structures of three aspartate aminotransferases (AATs) from eukaryotic pathogens were solved within the Seattle Structural Genomics Center for Infectious Disease (SSGCID). Both the open and closed conformations of AAT were observed. Pyridoxal phosphate was bound to the active site via a Schiff base to a conserved lysine. An active-site mutant showed that Trypanosoma brucei AAT still binds pyridoxal phosphate even in the absence of the tethering lysine. The structures highlight the challenges for the structure-based design of inhibitors targeting the active site, while showing options for inhibitor design targeting the N-terminal arm.
+Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.,Abendroth J, Choi R, Wall A, Clifton MC, Lukacs CM, Staker BL, Van Voorhis W, Myler P, Lorimer DD, Edwards TE Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):566-71. doi:, 10.1107/S2053230X15001831. Epub 2015 Apr 21. PMID:25945710<ref>PMID:25945710</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4w5k" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Aspartate Aminotransferase|Aspartate Aminotransferase]]
+*[[Aspartate aminotransferase 3D structures|Aspartate aminotransferase 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Aspartate transaminase]]
+[[Category: Large Structures]]
-[[Category: Structural genomic]]
+[[Category: Trypanosoma brucei brucei TREU927]]
-[[Category: Aspartate aminotransferase]]
-[[Category: Mitochondrial]]
-[[Category: Ssgcid]]
-[[Category: Trypanosoma brucei]]