4ttb: Difference between revisions
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==Crystal structure of homo sapiens IODOTYROSINE DEIODINASE (IYD) bound to FMN== | ==Crystal structure of homo sapiens IODOTYROSINE DEIODINASE (IYD) bound to FMN== | ||
<StructureSection load='4ttb' size='340' side='right' caption='[[4ttb]], [[Resolution|resolution]] 2.45Å' scene=''> | <StructureSection load='4ttb' size='340' side='right'caption='[[4ttb]], [[Resolution|resolution]] 2.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ttb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TTB OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4ttb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TTB FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.447Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ttb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ttb OCA], [https://pdbe.org/4ttb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ttb RCSB], [https://www.ebi.ac.uk/pdbsum/4ttb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ttb ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/IYD1_HUMAN IYD1_HUMAN] Familial thyroid dyshormonogenesis. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/IYD1_HUMAN IYD1_HUMAN] Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.<ref>PMID:15289438</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Dehalogenase|Dehalogenase]] | *[[Dehalogenase 3D structures|Dehalogenase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Chuenchor W]] | ||
[[Category: | [[Category: Hu J]] | ||
[[Category: | [[Category: Rokita S]] | ||