4tpw: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G==
-<StructureSection load='4tpw' size='340' side='right' caption='[[4tpw]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+<StructureSection load='4tpw' size='340' side='right'caption='[[4tpw]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4tpw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TPW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4tpw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TPW FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33R:(2E)-2-{2-[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]HYDRAZINYLIDENE}-3-(2-NITROPHENYL)PROPANOIC+ACID'>33R</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MGP:7-METHYL-GUANOSINE-5-TRIPHOSPHATE'>MGP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tpw OCA], [http://pdbe.org/4tpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tpw RCSB], [http://www.ebi.ac.uk/pdbsum/4tpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tpw ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=33R:(2E)-2-{2-[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]HYDRAZINYLIDENE}-3-(2-NITROPHENYL)PROPANOIC+ACID'>33R</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MGP:7-METHYL-GUANOSINE-5-TRIPHOSPHATE'>MGP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tpw OCA], [https://pdbe.org/4tpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tpw RCSB], [https://www.ebi.ac.uk/pdbsum/4tpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tpw ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
+[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 21: @@
 ==See Also==
-*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
+*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Jenni, S]]
+[[Category: Homo sapiens]]
-[[Category: Papadopoulos, E]]
+[[Category: Large Structures]]
-[[Category: Wagner, G]]
+[[Category: Jenni S]]
-[[Category: Allosteric]]
+[[Category: Papadopoulos E]]
-[[Category: Eif4e]]
+[[Category: Wagner G]]
-[[Category: Protein binding]]
-[[Category: Translation initiation inhibitor]]