4pl3: Difference between revisions
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==Crystal structure of murine IRE1 in complex with MKC9989 inhibitor== | ==Crystal structure of murine IRE1 in complex with MKC9989 inhibitor== | ||
<StructureSection load='4pl3' size='340' side='right' caption='[[4pl3]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='4pl3' size='340' side='right'caption='[[4pl3]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4pl3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL3 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4pl3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PL3 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=31J:7-HYDROXY-6-METHOXY-3-[2-(2-METHOXYETHOXY)ETHYL]-4,8-DIMETHYL-2H-CHROMEN-2-ONE'>31J</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=31J:7-HYDROXY-6-METHOXY-3-[2-(2-METHOXYETHOXY)ETHYL]-4,8-DIMETHYL-2H-CHROMEN-2-ONE'>31J</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pl3 OCA], [https://pdbe.org/4pl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pl3 RCSB], [https://www.ebi.ac.uk/pdbsum/4pl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pl3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ERN1_MOUSE ERN1_MOUSE] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:11850408</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4pl3" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4pl3" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Ire1|Ire1]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Al-awar | [[Category: Large Structures]] | ||
[[Category: Chiovitti | [[Category: Mus musculus]] | ||
[[Category: Duffy | [[Category: Al-awar R]] | ||
[[Category: Patterson | [[Category: Chiovitti D]] | ||
[[Category: Sanches | [[Category: Duffy N]] | ||
[[Category: Sicheri | [[Category: Patterson JB]] | ||
[[Category: Talukdar | [[Category: Sanches M]] | ||
[[Category: Thevakumaran | [[Category: Sicheri F]] | ||
[[Category: Talukdar M]] | |||
[[Category: Thevakumaran N]] | |||