5jw3: Difference between revisions

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 ==Structure of MEDI8852 Fab Fragment in Complex with H7 HA==
-<StructureSection load='5jw3' size='340' side='right' caption='[[5jw3]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
+<StructureSection load='5jw3' size='340' side='right'caption='[[5jw3]], [[Resolution|resolution]] 3.75&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5jw3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/turkey/italy/214845/2002(h7n3)) Influenza a virus (a/turkey/italy/214845/2002(h7n3))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW3 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5jw3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/turkey/Italy/214845/2002(H7N3)) Influenza A virus (A/turkey/Italy/214845/2002(H7N3))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JW3 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.75&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw3 OCA], [http://pdbe.org/5jw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw3 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw3 ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw3 OCA], [https://pdbe.org/5jw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jw3 RCSB], [https://www.ebi.ac.uk/pdbsum/5jw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw3 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/Q701U0_9INFA Q701U0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00363335]
+[https://www.uniprot.org/uniprot/Q6GYW3_9INFA Q6GYW3_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013829_004_327643]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 18: / Line 19: @@
 </div>
 <div class="pdbe-citations 5jw3" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Collins, P J]]
+[[Category: Homo sapiens]]
-[[Category: Gamblin, S J]]
+[[Category: Large Structures]]
-[[Category: Martin, S R]]
+[[Category: Collins PJ]]
-[[Category: Neu, U]]
+[[Category: Gamblin SJ]]
-[[Category: Ogrodowicz, R W]]
+[[Category: Martin SR]]
-[[Category: Skehel, J J]]
+[[Category: Neu U]]
-[[Category: Vorlaender, M K]]
+[[Category: Ogrodowicz RW]]
-[[Category: Walker, P A]]
+[[Category: Skehel JJ]]
-[[Category: Antibody influenza broadly neutralizing]]
+[[Category: Vorlaender MK]]
-[[Category: Immune system]]
+[[Category: Walker PA]]