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==Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60==
==Structure of beta2 adrenoceptor bound to carazolol and inactive-state stabilizing nanobody, Nb60==
<StructureSection load='5jqh' size='340' side='right' caption='[[5jqh]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='5jqh' size='340' side='right'caption='[[5jqh]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jqh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JQH FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jqh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JQH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAU:(2S)-1-(9H-CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)PROPAN-2-OL'>CAU</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jqh OCA], [http://pdbe.org/5jqh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jqh RCSB], [http://www.ebi.ac.uk/pdbsum/5jqh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jqh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jqh OCA], [https://pdbe.org/5jqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jqh RCSB], [https://www.ebi.ac.uk/pdbsum/5jqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jqh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4]] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jqh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jqh" style="background-color:#fffaf0;"></div>
==See Also==
*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lysozyme]]
[[Category: Escherichia virus T4]]
[[Category: Ahn, S]]
[[Category: Homo sapiens]]
[[Category: Chatterjee, A]]
[[Category: Lama glama]]
[[Category: Costa, T]]
[[Category: Large Structures]]
[[Category: Kahsai, A W]]
[[Category: Ahn S]]
[[Category: Kim, T H]]
[[Category: Chatterjee A]]
[[Category: Kobilka, B K]]
[[Category: Costa T]]
[[Category: Kruse, A C]]
[[Category: Kahsai AW]]
[[Category: Lefkowitz, R J]]
[[Category: Kim TH]]
[[Category: Manglik, A]]
[[Category: Kobilka BK]]
[[Category: Masoudi, A]]
[[Category: Kruse AC]]
[[Category: Pani, B]]
[[Category: Lefkowitz RJ]]
[[Category: Pardon, E]]
[[Category: Manglik A]]
[[Category: Prosser, R S]]
[[Category: Masoudi A]]
[[Category: Staus, D P]]
[[Category: Pani B]]
[[Category: Steyaert, J]]
[[Category: Pardon E]]
[[Category: Strachan, R T]]
[[Category: Prosser RS]]
[[Category: Weis, W I]]
[[Category: Staus DP]]
[[Category: Wingler, L M]]
[[Category: Steyaert J]]
[[Category: Allostery]]
[[Category: Strachan RT]]
[[Category: Gpcr]]
[[Category: Weis WI]]
[[Category: Hydrolase]]
[[Category: Wingler LM]]
[[Category: Hydrolase-inhibitor complex]]
[[Category: Nanobody]]
[[Category: Signaling]]
[[Category: Signaling protein]]

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