5jk5: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:


==Phenylalanine hydroxylase from dictyostelium - BH2 complex==
==Phenylalanine hydroxylase from dictyostelium - BH2 complex==
<StructureSection load='5jk5' size='340' side='right' caption='[[5jk5]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='5jk5' size='340' side='right'caption='[[5jk5]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jk5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JK5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jk5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JK5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=PIN:PIPERAZINE-N,N-BIS(2-ETHANESULFONIC+ACID)'>PIN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.071&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jk6|5jk6]], [[5jk8|5jk8]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HBI:7,8-DIHYDROBIOPTERIN'>HBI</scene>, <scene name='pdbligand=PIN:PIPERAZINE-N,N-BIS(2-ETHANESULFONIC+ACID)'>PIN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jk5 OCA], [http://pdbe.org/5jk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jk5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jk5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jk5 OCA], [https://pdbe.org/5jk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jk5 RCSB], [https://www.ebi.ac.uk/pdbsum/5jk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jk5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PH4H_DICDI PH4H_DICDI]] Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA. It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.<ref>PMID:18835579</ref>
[https://www.uniprot.org/uniprot/PH4H_DICDI PH4H_DICDI] Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA. It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.<ref>PMID:18835579</ref>  
 
==See Also==
*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lee, K H]]
[[Category: Dictyostelium discoideum]]
[[Category: Zhuang, N]]
[[Category: Large Structures]]
[[Category: Dictyostelium]]
[[Category: Lee KH]]
[[Category: Enzyme regulation]]
[[Category: Zhuang N]]
[[Category: Oxidoreductase]]
[[Category: Phenylalanine hydroxylase]]
[[Category: Tetrahydrobiopterin]]

Latest revision as of 21:56, 20 September 2023

Phenylalanine hydroxylase from dictyostelium - BH2 complexPhenylalanine hydroxylase from dictyostelium - BH2 complex

Structural highlights

5jk5 is a 2 chain structure with sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.071Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PH4H_DICDI Hydroxylates L-tryptophan to 5-hydroxy-L-tryptophan but does not hydroxylate L-tyrosine to L-DOPA. It uses D-threo-tetrahydrodictyopterin (DH4), also known as dictyoperin, as a cofactor.[1]

See Also

References

  1. ↑ Siltberg-Liberles J, Steen IH, Svebak RM, Martinez A. The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum. Gene. 2008 Dec 31;427(1-2):86-92. doi: 10.1016/j.gene.2008.09.005. Epub 2008 Sep , 16. PMID:18835579 doi:http://dx.doi.org/10.1016/j.gene.2008.09.005

5jk5, resolution 2.07Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5jk5&oldid=3880824"