7x3l: Difference between revisions

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-'''Unreleased structure'''
-The entry 7x3l is ON HOLD
+==Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044==
+<StructureSection load='7x3l' size='340' side='right'caption='[[7x3l]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7x3l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X3L FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8FO:(2~{R})-2-[4-(3-fluoranyl-4-methyl-phenyl)-3-(trifluoromethyl)phenyl]butanoic+acid'>8FO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x3l OCA], [https://pdbe.org/7x3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x3l RCSB], [https://www.ebi.ac.uk/pdbsum/7x3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x3l ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
-Authors: Jiang, J., Liu, Y., He, S., Chen, Y., Chu, X., Liu, Y., Guo, Q., Zhao, L., Feng, F., Liu, W., Zhang, X., Fang, P., Sun, H.
+==See Also==
+*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
-Description: Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: He, S]]
+[[Category: Homo sapiens]]
-[[Category: Liu, W]]
+[[Category: Large Structures]]
-[[Category: Fang, P]]
+[[Category: Chen Y]]
-[[Category: Jiang, J]]
+[[Category: Chu X]]
-[[Category: Chen, Y]]
+[[Category: Fang P]]
-[[Category: Zhang, X]]
+[[Category: Feng F]]
-[[Category: Guo, Q]]
+[[Category: Guo Q]]
-[[Category: Zhao, L]]
+[[Category: He S]]
-[[Category: Sun, H]]
+[[Category: Jiang J]]
-[[Category: Feng, F]]
+[[Category: Liu W]]
-[[Category: Liu, Y]]
+[[Category: Liu Y]]
-[[Category: Chu, X]]
+[[Category: Sun H]]
+[[Category: Zhang X]]
+[[Category: Zhao L]]