4rr4: Difference between revisions

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-'''Unreleased structure'''
-The entry 4rr4 is ON HOLD  until Paper Publication
+==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367==
+<StructureSection load='4rr4' size='340' side='right'caption='[[4rr4]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RR4 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3V1:2-CHLORO-N-[3-(4-{[(2Z)-2-CYANO-3-CYCLOPROPYL-3-HYDROXYPROP-2-ENOYL]AMINO}PHENOXY)PHENYL]-4-METHYL-1,3-THIAZOLE-5-CARBOXAMIDE'>3V1</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rr4 OCA], [https://pdbe.org/4rr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rr4 RCSB], [https://www.ebi.ac.uk/pdbsum/4rr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rr4 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
-Authors: Zhu, L., Ren, X., Zhu, J., Li, H.
+==See Also==
+*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
-Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li H]]
+[[Category: Ren X]]
+[[Category: Zhu J]]
+[[Category: Zhu L]]