4ro9: Difference between revisions

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 ==2.0A resolution structure of SRPN2 (S358E) from Anopheles gambiae==
-<StructureSection load='4ro9' size='340' side='right' caption='[[4ro9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+<StructureSection load='4ro9' size='340' side='right'caption='[[4ro9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ro9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoga Anoga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RO9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ro9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RO9 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4roa|4roa]], [[4rob|4rob]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SRPN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7165 ANOGA])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ro9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ro9 OCA], [https://pdbe.org/4ro9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ro9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ro9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ro9 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ro9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ro9 OCA], [http://pdbe.org/4ro9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ro9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ro9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ro9 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/SP2_ANOGA SP2_ANOGA] Serine protease inhibitor that functions in the melanization-mediated immune response (PubMed:16113656, PubMed:20953892, PubMed:33520733, PubMed:33045027, PubMed:21465556, PubMed:25525260). By preventing the activation of phenoloxidases through the inhibiting of serine proteases CLIPB9 and CLIPB10, negatively regulates melanization in the hemolymph (PubMed:16113656, PubMed:20953892, PubMed:33520733, PubMed:33045027, PubMed:21465556, PubMed:25525260). By preventing melanization, has a detrimental role during P.berghei parasite mediated-infection and invasion of the mosquito midgut (PubMed:16113656).<ref>PMID:16113656</ref> <ref>PMID:20953892</ref> <ref>PMID:21465556</ref> <ref>PMID:25525260</ref> <ref>PMID:33045027</ref> <ref>PMID:33520733</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 18: / Line 19: @@
 </div>
 <div class="pdbe-citations 4ro9" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Serpin 3D structures|Serpin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Anoga]]
+[[Category: Anopheles gambiae]]
-[[Category: An, C]]
+[[Category: Large Structures]]
-[[Category: Battaile, K P]]
+[[Category: An C]]
-[[Category: Lovell, S]]
+[[Category: Battaile KP]]
-[[Category: Meekins, D A]]
+[[Category: Lovell S]]
-[[Category: Michel, K]]
+[[Category: Meekins DA]]
-[[Category: Zhang, X]]
+[[Category: Michel K]]
-[[Category: Hydrolase inhibitor]]
+[[Category: Zhang X]]
-[[Category: Insect immunity]]
-[[Category: Serine protease inhibitor]]
-[[Category: Serpin]]