4r2a: Difference between revisions

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==Egr1/Zif268 zinc fingers in complex with methylated DNA==
==Egr1/Zif268 zinc fingers in complex with methylated DNA==
<StructureSection load='4r2a' size='340' side='right' caption='[[4r2a]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='4r2a' size='340' side='right'caption='[[4r2a]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4r2a]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R2A FirstGlance]. <br>
<table><tr><td colspan='2'>[[4r2a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R2A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.591&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r2c|4r2c]], [[4r2d|4r2d]], [[4r2e|4r2e]], [[4r2p|4r2p]], [[4r2q|4r2q]], [[4r2r|4r2r]], [[4r2s|4r2s]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r2a OCA], [https://pdbe.org/4r2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r2a RCSB], [https://www.ebi.ac.uk/pdbsum/4r2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r2a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r2a RCSB], [http://www.ebi.ac.uk/pdbsum/4r2a PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/EGR1_HUMAN EGR1_HUMAN]] Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.  
[https://www.uniprot.org/uniprot/EGR1_HUMAN EGR1_HUMAN] Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4r2a" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cheng, X]]
[[Category: Homo sapiens]]
[[Category: Hashimoto, H]]
[[Category: Large Structures]]
[[Category: Olanrewaju, Y O]]
[[Category: Synthetic construct]]
[[Category: Wilson, G G]]
[[Category: Cheng X]]
[[Category: Zhang, X]]
[[Category: Hashimoto H]]
[[Category: Zheng, Y]]
[[Category: Olanrewaju YO]]
[[Category: Dna binding protein-dna complex]]
[[Category: Wilson GG]]
[[Category: Transcription]]
[[Category: Zhang X]]
[[Category: Zinc finger]]
[[Category: Zheng Y]]

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