4qna: Difference between revisions

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 ==MST3 IN COMPLEX WITH 2-(4,6-Diamino-1,3,5-triazin-2-yl)phenol==
-<StructureSection load='4qna' size='340' side='right' caption='[[4qna]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
+<StructureSection load='4qna' size='340' side='right'caption='[[4qna]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4qna]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QNA FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4qna]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QNA FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=X11:2-(4,6-DIAMINO-1,3,5-TRIAZIN-2-YL)PHENOL'>X11</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.849&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=X11:2-(4,6-DIAMINO-1,3,5-TRIAZIN-2-YL)PHENOL'>X11</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qml|4qml]], [[4qmm|4qmm]], [[4qmn|4qmn]], [[4qmo|4qmo]], [[4qmq|4qmq]], [[4qmr|4qmr]], [[4qms|4qms]], [[4qmt|4qmt]], [[4qmu|4qmu]], [[4qmv|4qmv]], [[4qmw|4qmw]], [[4qmx|4qmx]], [[4qmy|4qmy]], [[4qmz|4qmz]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qna OCA], [https://pdbe.org/4qna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qna RCSB], [https://www.ebi.ac.uk/pdbsum/4qna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qna ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qna OCA], [http://pdbe.org/4qna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qna RCSB], [http://www.ebi.ac.uk/pdbsum/4qna PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/STK24_HUMAN STK24_HUMAN] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<ref>PMID:16314523</ref> <ref>PMID:17046825</ref> <ref>PMID:19604147</ref> <ref>PMID:19855390</ref> <ref>PMID:19782762</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 19: @@
 </div>
 <div class="pdbe-citations 4qna" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Homo sapiens]]
-[[Category: Olesen, S H]]
+[[Category: Large Structures]]
-[[Category: Schonbrunn, E]]
+[[Category: Olesen SH]]
-[[Category: Watts, C]]
+[[Category: Schonbrunn E]]
-[[Category: Zhu, J Y]]
+[[Category: Watts C]]
-[[Category: Atp-binding]]
+[[Category: Zhu J-Y]]
-[[Category: Mst3]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphoprotein]]
-[[Category: Protein kinase]]
-[[Category: Serine/threonine-transferase]]
-[[Category: Sterile 20-like kinase]]
-[[Category: Stk24]]
-[[Category: Transferase-transferase inhibitor complex]]