4px3: Difference between revisions

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-'''Unreleased structure'''
-The entry 4px3 is ON HOLD  until Paper Publication
+==Human GKRP bound to AMG-3295 and Sorbitol-6-phosphate==
+<StructureSection load='4px3' size='340' side='right'caption='[[4px3]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4px3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PX3 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2WX:N-[(R)-1-BENZOTHIOPHEN-2-YL(2-CHLOROPHENYL)METHYL]-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE-7-SULFONAMIDE'>2WX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4px3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4px3 OCA], [https://pdbe.org/4px3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4px3 RCSB], [https://www.ebi.ac.uk/pdbsum/4px3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4px3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN] Inhibits glucokinase by forming an inactive complex with this enzyme.
-Authors: Jordan, S.R., Chmait, S.
+==See Also==
+*[[Glucokinase Regulatory Protein|Glucokinase Regulatory Protein]]
-Description: Human GKRP bound to AMG-3295 and Sorbitol-6-phosphate
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chmait S]]
+[[Category: Jordan SR]]