4px2: Difference between revisions

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<StructureSection load='4px2' size='340' side='right'caption='[[4px2]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='4px2' size='340' side='right'caption='[[4px2]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4px2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PX2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4px2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PX2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WY:N-[(R)-1-BENZOFURAN-2-YL(PHENYL)METHYL]-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE-7-SULFONAMIDE'>2WY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4px3|4px3]], [[4px5|4px5]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2WY:N-[(R)-1-BENZOFURAN-2-YL(PHENYL)METHYL]-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE-7-SULFONAMIDE'>2WY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GCKR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4px2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4px2 OCA], [https://pdbe.org/4px2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4px2 RCSB], [https://www.ebi.ac.uk/pdbsum/4px2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4px2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4px2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4px2 OCA], [http://pdbe.org/4px2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4px2 RCSB], [http://www.ebi.ac.uk/pdbsum/4px2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4px2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN]] Inhibits glucokinase by forming an inactive complex with this enzyme.  
[https://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN] Inhibits glucokinase by forming an inactive complex with this enzyme.


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chmait, S]]
[[Category: Chmait S]]
[[Category: Jordan, S R]]
[[Category: Jordan SR]]
[[Category: Glucokinase]]
[[Category: Regulatory protein - binds to and inhibits glucokinase]]
[[Category: Sis domain containing protein]]
[[Category: Sugar binding protein-inhibitor complex]]

Latest revision as of 20:24, 20 September 2023

Human GKRP bound to AMG2882 and Sorbitol-6-PhosphateHuman GKRP bound to AMG2882 and Sorbitol-6-Phosphate

Structural highlights

4px2 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.15Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GCKR_HUMAN Inhibits glucokinase by forming an inactive complex with this enzyme.

See Also

4px2, resolution 2.15Å

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