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==Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine (D-(S)-LeuP)==
==Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine (D-(S)-LeuP)==
<StructureSection load='4pvb' size='340' side='right' caption='[[4pvb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4pvb' size='340' side='right'caption='[[4pvb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4pvb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PVB FirstGlance]. <br>
<table><tr><td colspan='2'>[[4pvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_MC58 Neisseria meningitidis MC58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PVB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WW:[(1S)-1-AMINO-3-METHYLBUTYL]PHOSPHONIC+ACID'>2WW</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2WW:[(1S)-1-AMINO-3-METHYLBUTYL]PHOSPHONIC+ACID'>2WW</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pu2|4pu2]], [[2gtq|2gtq]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvb OCA], [https://pdbe.org/4pvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pvb RCSB], [https://www.ebi.ac.uk/pdbsum/4pvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvb ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Membrane_alanyl_aminopeptidase Membrane alanyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.2 3.4.11.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pvb OCA], [http://pdbe.org/4pvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pvb RCSB], [http://www.ebi.ac.uk/pdbsum/4pvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pvb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9JYV4_NEIMB Q9JYV4_NEIMB]


==See Also==
==See Also==
*[[Aminopeptidase|Aminopeptidase]]
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Membrane alanyl aminopeptidase]]
[[Category: Large Structures]]
[[Category: Berlicki, L]]
[[Category: Neisseria meningitidis MC58]]
[[Category: Joachimak, A]]
[[Category: Berlicki L]]
[[Category: Structural genomic]]
[[Category: Joachimiak A]]
[[Category: Mucha, A]]
[[Category: Mucha A]]
[[Category: Mulligan, R]]
[[Category: Mulligan R]]
[[Category: Nocek, B]]
[[Category: Nocek B]]
[[Category: Vassiliou, S]]
[[Category: Vassiliou S]]
[[Category: Aminopeptidase n]]
[[Category: Apn]]
[[Category: Hydrolase]]
[[Category: Mcsg]]
[[Category: Psi-biology]]

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