4pu5: Difference between revisions

<StructureSection load='4pu5' size='340' side='right'caption='[[4pu5]], [[Resolution|resolution]] 1.83&Aring;' scene=''>

<table><tr><td colspan='2'>[[4pu5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Shewanella_oneidensis_MR-1 Shewanella oneidensis MR-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PU5 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.834&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pu5 OCA], [https://pdbe.org/4pu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pu5 RCSB], [https://www.ebi.ac.uk/pdbsum/4pu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pu5 ProSAT]</span></td></tr>

</table>

[https://www.uniprot.org/uniprot/HIPA_SHEON HIPA_SHEON] Toxic component of a type II toxin-antitoxin (TA) system; overexpression in wild-type temporarily inhibits cell growth, overexpression in a hipAB deletion leads to acute growth inhibition. The toxic effect of HipA is neutralized by its cognate antitoxin HipB. In the ternary phosphoserine-HipA-HipB-DNA complex the DNA is bent about 125 degrees; all HipA in the crystallized ternary complex is phosphorylated. In E.coli phosphorylation of HipA is thought to release HipB from the HipA-HipB-DNA complex, suggesting the complex functions differently in the 2 bacteria (PubMed:25056321). Phosphorylates Glu-tRNA-ligase (GltX, on 'Ser-239') in vivo, with HipB probably acts as a corepressor for transcription of the hipBA promoter (By similarity).[UniProtKB:P23874]<ref>PMID:25056321</ref>  

[[Category: Behiels E]]

[[Category: Devreese B]]

[[Category: Elegheert J]]

[[Category: Felix J]]

[[Category: Savvides S]]

[[Category: Vergauwen B]]

[[Category: Wen Y]]