4pu4: Difference between revisions
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<StructureSection load='4pu4' size='340' side='right'caption='[[4pu4]], [[Resolution|resolution]] 3.79Å' scene=''> | <StructureSection load='4pu4' size='340' side='right'caption='[[4pu4]], [[Resolution|resolution]] 3.79Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4pu4]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4pu4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Shewanella_oneidensis Shewanella oneidensis] and [https://en.wikipedia.org/wiki/Shewanella_oneidensis_MR-1 Shewanella oneidensis MR-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PU4 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.786Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pu4 OCA], [https://pdbe.org/4pu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pu4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pu4 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HIPA_SHEON HIPA_SHEON] Toxic component of a type II toxin-antitoxin (TA) system; overexpression in wild-type temporarily inhibits cell growth, overexpression in a hipAB deletion leads to acute growth inhibition. The toxic effect of HipA is neutralized by its cognate antitoxin HipB. In the ternary phosphoserine-HipA-HipB-DNA complex the DNA is bent about 125 degrees; all HipA in the crystallized ternary complex is phosphorylated. In E.coli phosphorylation of HipA is thought to release HipB from the HipA-HipB-DNA complex, suggesting the complex functions differently in the 2 bacteria (PubMed:25056321). Phosphorylates Glu-tRNA-ligase (GltX, on 'Ser-239') in vivo, with HipB probably acts as a corepressor for transcription of the hipBA promoter (By similarity).[UniProtKB:P23874]<ref>PMID:25056321</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Shewanella oneidensis]] | ||
[[Category: Behiels | [[Category: Shewanella oneidensis MR-1]] | ||
[[Category: Devreese | [[Category: Behiels E]] | ||
[[Category: Elegheert | [[Category: Devreese B]] | ||
[[Category: Felix | [[Category: Elegheert J]] | ||
[[Category: Savvides | [[Category: Felix J]] | ||
[[Category: Vergauwen | [[Category: Savvides S]] | ||
[[Category: Wen | [[Category: Vergauwen B]] | ||
[[Category: Wen Y]] | |||