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==single room temperature model of DHFR==
==single room temperature model of DHFR==
<StructureSection load='4nx6' size='340' side='right' caption='[[4nx6]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='4nx6' size='340' side='right'caption='[[4nx6]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nx6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NX6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NX6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nx6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NX6 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kjk|4kjk]], [[4nx7|4nx7]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folA, tmrA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nx6 OCA], [https://pdbe.org/4nx6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nx6 RCSB], [https://www.ebi.ac.uk/pdbsum/4nx6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nx6 ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nx6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nx6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nx6 RCSB], [http://www.ebi.ac.uk/pdbsum/4nx6 PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR.,Fenwick RB, van den Bedem H, Fraser JS, Wright PE Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E445-54. doi:, 10.1073/pnas.1323440111. Epub 2014 Jan 13. PMID:24474795<ref>PMID:24474795</ref>
Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR.,Fenwick RB, van den Bedem H, Fraser JS, Wright PE Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E445-54. doi:, 10.1073/pnas.1323440111. Epub 2014 Jan 13. PMID:24474795<ref>PMID:24474795</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4nx6" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dihydrofolate reductase]]
[[Category: Escherichia coli K-12]]
[[Category: Ecoli]]
[[Category: Large Structures]]
[[Category: Bedem, H van den.]]
[[Category: Fenwick RB]]
[[Category: Fenwick, R B.]]
[[Category: Fraser JS]]
[[Category: Fraser, J S.]]
[[Category: Wright PE]]
[[Category: Wright, P E.]]
[[Category: Van den Bedem H]]
[[Category: Folate metabolism]]
[[Category: Oxidoreductase]]

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