4nsp: Difference between revisions

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OCA

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 ==Crystal structure of human ENDOV==
-<StructureSection load='4nsp' size='340' side='right' caption='[[4nsp]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='4nsp' size='340' side='right'caption='[[4nsp]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4nsp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NSP FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4nsp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NSP FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nsp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nsp RCSB], [http://www.ebi.ac.uk/pdbsum/4nsp PDBsum]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-<table>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nsp OCA], [https://pdbe.org/4nsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nsp RCSB], [https://www.ebi.ac.uk/pdbsum/4nsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nsp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ENDOV_HUMAN ENDOV_HUMAN] Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.<ref>PMID:23139746</ref> <ref>PMID:23912683</ref> <ref>PMID:23912718</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4nsp" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Endonuclease 3D structures|Endonuclease 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Hao, Z.]]
+[[Category: Homo sapiens]]
-[[Category: Xie, W.]]
+[[Category: Large Structures]]
-[[Category: Zhang, Z.]]
+[[Category: Hao Z]]
-[[Category: Hydrolase]]
+[[Category: Xie W]]
-[[Category: Raase h-like motif]]
+[[Category: Zhang Z]]