4npp: Difference between revisions
No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==The GLIC-His10 wild-type structure in equilibrium between the open and locally-closed (LC) forms== | ==The GLIC-His10 wild-type structure in equilibrium between the open and locally-closed (LC) forms== | ||
<StructureSection load='4npp' size='340' side='right' caption='[[4npp]], [[Resolution|resolution]] 3.35Å' scene=''> | <StructureSection load='4npp' size='340' side='right'caption='[[4npp]], [[Resolution|resolution]] 3.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4npp]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4npp]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4npp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npp OCA], [https://pdbe.org/4npp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npp RCSB], [https://www.ebi.ac.uk/pdbsum/4npp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npp ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 21: | ||
==See Also== | ==See Also== | ||
*[[Ion channels|Ion channels]] | *[[Ion channels 3D structures|Ion channels 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Gloeobacter violaceus PCC 7421]] | ||
[[Category: Changeux | [[Category: Large Structures]] | ||
[[Category: Corringer | [[Category: Changeux JP]] | ||
[[Category: Delarue | [[Category: Corringer PJ]] | ||
[[Category: Haouz | [[Category: Delarue M]] | ||
[[Category: Huon | [[Category: Haouz A]] | ||
[[Category: Menny | [[Category: Huon C]] | ||
[[Category: Nemecz | [[Category: Menny A]] | ||
[[Category: Poitevin | [[Category: Nemecz A]] | ||
[[Category: Sauguet | [[Category: Poitevin F]] | ||
[[Category: Shahsavar | [[Category: Sauguet L]] | ||
[[Category: Shahsavar A]] | |||