4n8q: Difference between revisions

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==Alternative substrates of Mycobacterium tuberculosis anthranilate phosphoribosyl transferase==
==Alternative substrates of Mycobacterium tuberculosis anthranilate phosphoribosyl transferase==
<StructureSection load='4n8q' size='340' side='right' caption='[[4n8q]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
<StructureSection load='4n8q' size='340' side='right'caption='[[4n8q]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4n8q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N8Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[4n8q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N8Q FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FA0:2-AMINO-4-FLUOROBENZOIC+ACID'>FA0</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bpq|2bpq]], [[3qr9|3qr9]], [[4n5v|4n5v]], [[4n93|4n93]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FA0:2-AMINO-4-FLUOROBENZOIC+ACID'>FA0</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT2248, MTCY190.03c, Rv2192c, trpD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8q OCA], [https://pdbe.org/4n8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n8q RCSB], [https://www.ebi.ac.uk/pdbsum/4n8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n8q ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anthranilate_phosphoribosyltransferase Anthranilate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18 2.4.2.18] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n8q RCSB], [http://www.ebi.ac.uk/pdbsum/4n8q PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/TRPD_MYCTU TRPD_MYCTU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.,Cookson TV, Castell A, Bulloch EM, Evans GL, Short FL, Baker EN, Lott JS, Parker EJ Biochem J. 2014 Apr 9. PMID:24712732<ref>PMID:24712732</ref>
Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.,Cookson TV, Castell A, Bulloch EM, Evans GL, Short FL, Baker EN, Lott JS, Parker EJ Biochem J. 2014 Apr 9. PMID:24712732<ref>PMID:24712732</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4n8q" style="background-color:#fffaf0;"></div>
==See Also==
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Anthranilate phosphoribosyltransferase]]
[[Category: Large Structures]]
[[Category: Baker, E N.]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Bulloch, E.]]
[[Category: Baker EN]]
[[Category: Castell, A.]]
[[Category: Bulloch E]]
[[Category: Cookson, T V.M.]]
[[Category: Castell A]]
[[Category: Evans, G L.]]
[[Category: Cookson TVM]]
[[Category: Lott, J S.]]
[[Category: Evans GL]]
[[Category: Parker, E J.]]
[[Category: Lott JS]]
[[Category: Anthranilate phosphoribosyltransferase]]
[[Category: Parker EJ]]
[[Category: Anthranilic acid]]
[[Category: Inhibitor]]
[[Category: Magnesium]]
[[Category: Magnesium binding phosphoribosyl pyrophosphate]]
[[Category: Transferase]]
[[Category: Tryptophan]]

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