4n8m: Difference between revisions
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==Structural polymorphism in the N-terminal oligomerization domain of NPM1== | ==Structural polymorphism in the N-terminal oligomerization domain of NPM1== | ||
<StructureSection load='4n8m' size='340' side='right' caption='[[4n8m]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4n8m' size='340' side='right'caption='[[4n8m]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4n8m]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4n8m]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N8M FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.802Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n8m OCA], [https://pdbe.org/4n8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n8m RCSB], [https://www.ebi.ac.uk/pdbsum/4n8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n8m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NPM_MOUSE NPM_MOUSE] Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules (By similarity). Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication (By similarity). Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4n8m" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Babu | [[Category: Mus musculus]] | ||
[[Category: Buljan | [[Category: Babu MM]] | ||
[[Category: Kriwacki | [[Category: Buljan M]] | ||
[[Category: Mitrea | [[Category: Kriwacki RW]] | ||
[[Category: Nourse | [[Category: Mitrea D]] | ||
[[Category: Park | [[Category: Nourse A]] | ||
[[Category: Pytel | [[Category: Park C]] | ||
[[Category: Royappa | [[Category: Pytel N]] | ||
[[Category: Satumba | [[Category: Royappa G]] | ||
[[Category: White | [[Category: Satumba J]] | ||
[[Category: Yun | [[Category: White SW]] | ||
[[Category: Yun M]] | |||