4mx1: Difference between revisions
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==Structure of ricin A chain bound with 2-amino-4-oxo-N-(2-(3-phenylureido)ethyl)-3,4-dihydropteridine-7-carboxamide== | ==Structure of ricin A chain bound with 2-amino-4-oxo-N-(2-(3-phenylureido)ethyl)-3,4-dihydropteridine-7-carboxamide== | ||
<StructureSection load='4mx1' size='340' side='right' caption='[[4mx1]], [[Resolution|resolution]] 1.59Å' scene=''> | <StructureSection load='4mx1' size='340' side='right'caption='[[4mx1]], [[Resolution|resolution]] 1.59Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mx1]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4mx1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MX1 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MX:2-AMINO-4-OXO-N-{2-[(PHENYLCARBAMOYL)AMINO]ETHYL}-3,4-DIHYDROPTERIDINE-7-CARBOXAMIDE'>1MX</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MX:2-AMINO-4-OXO-N-{2-[(PHENYLCARBAMOYL)AMINO]ETHYL}-3,4-DIHYDROPTERIDINE-7-CARBOXAMIDE'>1MX</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mx1 OCA], [https://pdbe.org/4mx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mx1 RCSB], [https://www.ebi.ac.uk/pdbsum/4mx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mx1 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4mx1" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4mx1" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Ricin 3D structures|Ricin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Ricinus communis]] | ||
[[Category: Anslyn | [[Category: Anslyn EV]] | ||
[[Category: Gao | [[Category: Gao G]] | ||
[[Category: Jasheway | [[Category: Jasheway KR]] | ||
[[Category: Manzano | [[Category: Manzano LA]] | ||
[[Category: Monzingo | [[Category: Monzingo AF]] | ||
[[Category: Pruet | [[Category: Pruet JM]] | ||
[[Category: Robertus | [[Category: Robertus JD]] | ||
[[Category: Saito | [[Category: Saito R]] | ||
[[Category: Wiget | [[Category: Wiget PA]] | ||