4mw7: Difference between revisions

Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
==Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(5-chloro-2-ethoxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1469)==
==Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(5-chloro-2-ethoxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1469)==
<StructureSection load='4mw7' size='340' side='right' caption='[[4mw7]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='4mw7' size='340' side='right'caption='[[4mw7]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mw7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MW7 OCA]. <br>
<table><tr><td colspan='2'>[[4mw7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MW7 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2EF:1-{3-[(5-CHLORO-2-ETHOXY-3-IODOBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA'>2EF</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2EF:1-{3-[(5-CHLORO-2-ETHOXY-3-IODOBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA'>2EF</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eg1|4eg1]], [[4eg3|4eg3]], [[4eg5|4eg5]], [[4mvw|4mvw]], [[4mvx|4mvx]], [[4mvy|4mvy]], [[4mw0|4mw0]], [[4mw1|4mw1]], [[4mw2|4mw2]], [[4mw4|4mw4]], [[4mw5|4mw5]], [[4mw6|4mw6]], [[4mw9|4mw9]], [[4mwb|4mwb]], [[4mwc|4mwc]], [[4mwd|4mwd]], [[4mwe|4mwe]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mw7 OCA], [https://pdbe.org/4mw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mw7 RCSB], [https://www.ebi.ac.uk/pdbsum/4mw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mw7 ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mw7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mw7 RCSB], [http://www.ebi.ac.uk/pdbsum/4mw7 PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/Q38C91_TRYB2 Q38C91_TRYB2]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 15: Line 16:
Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.,Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2775. doi: 10.1371/journal.pntd.0002775., eCollection 2014 Apr. PMID:24743796<ref>PMID:24743796</ref>
Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.,Koh CY, Kim JE, Wetzel AB, de van der Schueren WJ, Shibata S, Ranade RM, Liu J, Zhang Z, Gillespie JR, Buckner FS, Verlinde CL, Fan E, Hol WG PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2775. doi: 10.1371/journal.pntd.0002775., eCollection 2014 Apr. PMID:24743796<ref>PMID:24743796</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4mw7" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Methionine--tRNA ligase]]
[[Category: Large Structures]]
[[Category: Fan, E.]]
[[Category: Trypanosoma brucei]]
[[Category: Hol, W G.J.]]
[[Category: Fan E]]
[[Category: Kim, J E.]]
[[Category: Hol WGJ]]
[[Category: Koh, C Y.]]
[[Category: Kim JE]]
[[Category: Liu, J.]]
[[Category: Koh CY]]
[[Category: Schueren, W J.de van der.]]
[[Category: Liu J]]
[[Category: Shibata, S.]]
[[Category: Shibata S]]
[[Category: Verlinde, C L.M J.]]
[[Category: Verlinde CLMJ]]
[[Category: Wetzel, A B.]]
[[Category: Wetzel AB]]
[[Category: Zhang, Z.]]
[[Category: Zhang Z]]
[[Category: Aar]]
[[Category: De van der Schueren WJ]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Metr]]
[[Category: Nucleotide binding]]
[[Category: Parasite]]
[[Category: Protein-inhibitor complex]]
[[Category: Rossmann fold]]
[[Category: Translation]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/w/4mw7"