4mun: Difference between revisions

<StructureSection load='4mun' size='340' side='right'caption='[[4mun]], [[Resolution|resolution]] 1.57&Aring;' scene=''>

<table><tr><td colspan='2'>[[4mun]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MUN FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DZ:[5-METHOXY-2-({[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]SULFONYL}CARBAMOYL)-1H-INDOL-1-YL]ACETIC+ACID'>2DZ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mun OCA], [https://pdbe.org/4mun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mun RCSB], [https://www.ebi.ac.uk/pdbsum/4mun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mun ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Ligand efficiency has proven to be a valuable concept for optimization of leads in the early stages of drug design. Taking this one step further, group efficiency (GE) evaluates the binding efficiency of each appendage of a molecule, further fine-tuning the drug design process. Here, GE analysis is used to systematically improve the potency of inhibitors of Mycobacterium tuberculosis pantothenate synthetase, an important target in tuberculosis therapy. Binding efficiencies were found to be distributed unevenly within a lead molecule derived using a fragment-based approach. Substitution of the less efficient parts of the molecule allowed systematic development of more potent compounds. This method of dissecting and analyzing different groups within a molecule offers a rational and general way of carrying out lead optimization, with potential broad application within drug discovery.

 

Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis.,Hung AW, Silvestre HL, Wen S, George GP, Boland J, Blundell TL, Ciulli A, Abell C ChemMedChem. 2016 Jan 5;11(1):38-42. doi: 10.1002/cmdc.201500414. Epub 2015 Oct, 21. PMID:26486566<ref>PMID:26486566</ref>

 

 

[[Category: Large Structures]]

[[Category: Mycobacterium tuberculosis]]

[[Category: Blundell TL]]

[[Category: Silvestre HL]]