4msh: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==Crystal Structure of PDE10A2 with fragment ZT0143 ((2S)-4-chloro-2,3-dihydro-1,3-benzothiazol-2-amine)==
-<StructureSection load='4msh' size='340' side='right' caption='[[4msh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+<StructureSection load='4msh' size='340' side='right'caption='[[4msh]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4msh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSH OCA]. <br>
+<table><tr><td colspan='2'>[[4msh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MSH FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2D0:4-CHLORO-1,3-BENZOTHIAZOL-2-AMINE'>2D0</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mrw|4mrw]], [[4mrz|4mrz]], [[4ms0|4ms0]], [[4msa|4msa]], [[4msc|4msc]], [[4mse|4mse]], [[4msn|4msn]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2D0:4-CHLORO-1,3-BENZOTHIAZOL-2-AMINE'>2D0</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4msh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4msh OCA], [https://pdbe.org/4msh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4msh RCSB], [https://www.ebi.ac.uk/pdbsum/4msh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4msh ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4msh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4msh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4msh RCSB], [http://www.ebi.ac.uk/pdbsum/4msh PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 16: @@
 Identification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray Crystallography.,Recht MI, Sridhar V, Badger J, Bounaud PY, Logan C, Chie-Leon B, Nienaber V, Torres FE J Biomol Screen. 2013 Dec 27. PMID:24375910<ref>PMID:24375910</ref>
-From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4msh" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Badger, J.]]
+[[Category: Homo sapiens]]
-[[Category: Chie-Leon, B.]]
+[[Category: Large Structures]]
-[[Category: Logan, C.]]
+[[Category: Badger J]]
-[[Category: Nienaber, V.]]
+[[Category: Chie-Leon B]]
-[[Category: Sridhar, V.]]
+[[Category: Logan C]]
-[[Category: Fragment screening]]
+[[Category: Nienaber V]]
-[[Category: Hydrolase]]
+[[Category: Sridhar V]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]