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{{STRUCTURE_4mqb|  PDB=4mqb  |  SCENE=  }}
===Crystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acid===


==Function==
==Crystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acid==
[[http://www.uniprot.org/uniprot/KTHY_STAAM KTHY_STAAM]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).  
<StructureSection load='4mqb' size='340' side='right'caption='[[4mqb]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mqb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MQB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqb OCA], [https://pdbe.org/4mqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mqb RCSB], [https://www.ebi.ac.uk/pdbsum/4mqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KTHY_STAAM KTHY_STAAM] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).


==About this Structure==
==See Also==
[[4mqb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_mu50 Staphylococcus aureus subsp. aureus mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQB OCA].
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
[[Category: Staphylococcus aureus subsp. aureus mu50]]
__TOC__
[[Category: DTMP kinase]]
</StructureSection>
[[Category: Anderson, W F.]]
[[Category: Large Structures]]
[[Category: Babnigg, G.]]
[[Category: Staphylococcus aureus subsp. aureus Mu50]]
[[Category: Filippova, E V.]]
[[Category: Anderson WF]]
[[Category: Jedrzejczak, R.]]
[[Category: Babnigg G]]
[[Category: Joachimiak, A.]]
[[Category: Filippova EV]]
[[Category: Kiryukhina, O.]]
[[Category: Jedrzejczak R]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Joachimiak A]]
[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors.]]
[[Category: Kiryukhina O]]
[[Category: Minasov, G.]]
[[Category: Minasov G]]
[[Category: Rubin, E.]]
[[Category: Rubin E]]
[[Category: Sacchettini, J.]]
[[Category: Sacchettini J]]
[[Category: Shuvalova, L.]]
[[Category: Shuvalova L]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Mtb proteins conferring susceptibility to known mtb inhibitor]]
[[Category: Mtbi]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
[[Category: Thymidylate kinase]]
[[Category: Transferase]]

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