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==1.65A resolution structure of ToxT from Vibrio cholerae (P21 Form)== | ==1.65A resolution structure of ToxT from Vibrio cholerae (P21 Form)== | ||
<StructureSection load='4mlo' size='340' side='right' caption='[[4mlo]], [[Resolution|resolution]] 1.65Å' scene=''> | <StructureSection load='4mlo' size='340' side='right'caption='[[4mlo]], [[Resolution|resolution]] 1.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mlo]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4mlo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MLO FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mlo OCA], [https://pdbe.org/4mlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mlo RCSB], [https://www.ebi.ac.uk/pdbsum/4mlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mlo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q7BGC0_VIBCL Q7BGC0_VIBCL] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 17: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 4mlo" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4mlo" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[ToxT|ToxT]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Battaile | [[Category: Vibrio cholerae]] | ||
[[Category: Egan | [[Category: Battaile KP]] | ||
[[Category: Li | [[Category: Egan S]] | ||
[[Category: Lovell | [[Category: Li J]] | ||
[[Category: Wehmeyer | [[Category: Lovell S]] | ||
[[Category: Wehmeyer G]] | |||
Latest revision as of 19:39, 20 September 2023
1.65A resolution structure of ToxT from Vibrio cholerae (P21 Form)1.65A resolution structure of ToxT from Vibrio cholerae (P21 Form)
Structural highlights
FunctionPublication Abstract from PubMedToxT is an AraC-family transcriptional activator protein that controls the expression of key virulence factors in Vibrio cholerae, the causative agent of cholera. ToxT directly activates the expression of the genes that encode the toxin-coregulated pilus and cholera toxin, and also positively auto-regulates its own expression from the tcp promoter. The crystal structure of ToxT has previously been solved at 1.9 A resolution (PDB entry 3gbg). In this study, a crystal structure of ToxT at 1.65 A resolution with a similar overall structure to the previously determined structure is reported. However, there are distinct differences between the two structures, particularly in the region that extends from Asp101 to Glu110. This region, which can influence ToxT activity but was disordered in the previous structure, can be traced entirely in the current structure. 1.65 A resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae.,Li J, Wehmeyer G, Lovell S, Battaile KP, Egan SM Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):726-31. doi:, 10.1107/S2053230X1601298X. Epub 2016 Aug 26. PMID:27599865[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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