4mh0: Difference between revisions

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==Selective activation of Epac1 and Epac2==
==Selective activation of Epac1 and Epac2==
<StructureSection load='4mh0' size='340' side='right' caption='[[4mh0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4mh0' size='340' side='right'caption='[[4mh0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mh0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MH0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mh0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MH0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HR4:(2S,4AR,6R,7R,7AS)-6-{6-AMINO-8-[(4-FLUOROBENZYL)SULFANYL]-9H-PURIN-9-YL}-2-SULFANYLTETRAHYDRO-4H-FURO[3,2-D][1,3,2]DIOXAPHOSPHININ-7-OL+2-OXIDE'>HR4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2byv|2byv]], [[3cf6|3cf6]], [[4mgi|4mgi]], [[4mgk|4mgk]], [[4mgy|4mgy]], [[4mgz|4mgz]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HR4:(2S,4AR,6R,7R,7AS)-6-{6-AMINO-8-[(4-FLUOROBENZYL)SULFANYL]-9H-PURIN-9-YL}-2-SULFANYLTETRAHYDRO-4H-FURO[3,2-D][1,3,2]DIOXAPHOSPHININ-7-OL+2-OXIDE'>HR4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mh0 OCA], [http://pdbe.org/4mh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mh0 RCSB], [http://www.ebi.ac.uk/pdbsum/4mh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mh0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mh0 OCA], [https://pdbe.org/4mh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mh0 RCSB], [https://www.ebi.ac.uk/pdbsum/4mh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mh0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE]] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref> [[http://www.uniprot.org/uniprot/RAP1B_HUMAN RAP1B_HUMAN]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.<ref>PMID:20332120</ref> <ref>PMID:18660803</ref> 
[https://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref>  
 
==See Also==
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Rehmann, H]]
[[Category: Homo sapiens]]
[[Category: Guanine nucleotide exchange factor]]
[[Category: Large Structures]]
[[Category: Nucleotide binding]]
[[Category: Mus musculus]]
[[Category: Signaling protein-gtp-binding protein complex]]
[[Category: Rehmann H]]

Latest revision as of 19:37, 20 September 2023

Selective activation of Epac1 and Epac2Selective activation of Epac1 and Epac2

Structural highlights

4mh0 is a 2 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RPGF4_MOUSE Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.[1]

See Also

References

  1. ↑ Ozaki N, Shibasaki T, Kashima Y, Miki T, Takahashi K, Ueno H, Sunaga Y, Yano H, Matsuura Y, Iwanaga T, Takai Y, Seino S. cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11. PMID:11056535 doi:http://dx.doi.org/10.1038/35041046

4mh0, resolution 2.40Å

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