4mh0: Difference between revisions

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-'''Unreleased structure'''
-The entry 4mh0 is ON HOLD
+==Selective activation of Epac1 and Epac2==
+<StructureSection load='4mh0' size='340' side='right'caption='[[4mh0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4mh0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MH0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HR4:(2S,4AR,6R,7R,7AS)-6-{6-AMINO-8-[(4-FLUOROBENZYL)SULFANYL]-9H-PURIN-9-YL}-2-SULFANYLTETRAHYDRO-4H-FURO[3,2-D][1,3,2]DIOXAPHOSPHININ-7-OL+2-OXIDE'>HR4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mh0 OCA], [https://pdbe.org/4mh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mh0 RCSB], [https://www.ebi.ac.uk/pdbsum/4mh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mh0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref>
-Authors: Rehmann, H.
+==See Also==
+*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
-Description: Selective activation of Epac1 and Epac2
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Rehmann H]]