4m61: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4m61]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M61 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4m61]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M61 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m61 OCA], [https://pdbe.org/4m61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m61 RCSB], [https://www.ebi.ac.uk/pdbsum/4m61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m61 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m61 OCA], [https://pdbe.org/4m61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m61 RCSB], [https://www.ebi.ac.uk/pdbsum/4m61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m61 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 19:32, 20 September 2023
Crystal structure of unliganded anti-DNA Fab A52Crystal structure of unliganded anti-DNA Fab A52
Structural highlights
Publication Abstract from PubMedA52 is a murine monoclonal antibody isolated from autoimmune New Zealand Black/New Zealand White F1 mice that recognizes single and double stranded DNA. This mouse strain spontaneously develops systemic lupus erythematosus-like symptoms and has served as a model for that disease for many years. The 1.62 A crystal structure of the A52 Fab fragment reveals an H3 complementarity determining region with four closely spaced arginine residues, creating a positively charged surface to accommodate bound DNA. Proteins 2014. (c) 2014 Wiley Periodicals, Inc. Crystal structure determination of anti-DNA Fab A52.,Stanfield RL, Eilat D Proteins. 2014 Jan 22. doi: 10.1002/prot.24514. PMID:24449198[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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