4m18: Difference between revisions
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==Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man)== | ==Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man)== | ||
<StructureSection load='4m18' size='340' side='right' caption='[[4m18]], [[Resolution|resolution]] 3.20Å' scene=''> | <StructureSection load='4m18' size='340' side='right'caption='[[4m18]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4m18]] is a 12 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4m18]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M18 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.203Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PRD_900111:2alpha-alpha-mannobiose'>PRD_900111</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m18 OCA], [https://pdbe.org/4m18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m18 RCSB], [https://www.ebi.ac.uk/pdbsum/4m18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m18 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/SFTPD_HUMAN SFTPD_HUMAN] Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4m18" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Allen | [[Category: Large Structures]] | ||
[[Category: Cafarella | [[Category: Allen K]] | ||
[[Category: Calin | [[Category: Cafarella TR]] | ||
[[Category: Crouch | [[Category: Calin O]] | ||
[[Category: Goh | [[Category: Crouch EC]] | ||
[[Category: Hartshorn | [[Category: Goh BC]] | ||
[[Category: Rynkiewicz | [[Category: Hartshorn KL]] | ||
[[Category: Schulten | [[Category: Rynkiewicz MJ]] | ||
[[Category: Seaton | [[Category: Schulten K]] | ||
[[Category: Seeberger | [[Category: Seaton BA]] | ||
[[Category: White | [[Category: Seeberger PH]] | ||
[[Category: White MR]] | |||