4m0q: Difference between revisions

<StructureSection load='4m0q' size='340' side='right'caption='[[4m0q]], [[Resolution|resolution]] 1.92&Aring;' scene=''>

<table><tr><td colspan='2'>[[4m0q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M0Q FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.921&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m0q OCA], [https://pdbe.org/4m0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m0q RCSB], [https://www.ebi.ac.uk/pdbsum/4m0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m0q ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/VP24_EBOZM VP24_EBOZM] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.<ref>PMID:12191476</ref> <ref>PMID:12525613</ref> <ref>PMID:15220407</ref> <ref>PMID:17928350</ref>  

[[Category: Large Structures]]

[[Category: Zaire ebolavirus]]

[[Category: Amarasinghe GK]]

[[Category: Borek D]]

[[Category: Leung DW]]

[[Category: Xu W]]