4lr6: Difference between revisions
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==Structure of BRD4 bromodomain 1 with a 3-methyl-4-phenylisoxazol-5-amine fragment== | ==Structure of BRD4 bromodomain 1 with a 3-methyl-4-phenylisoxazol-5-amine fragment== | ||
<StructureSection load='4lr6' size='340' side='right' caption='[[4lr6]], [[Resolution|resolution]] 1.29Å' scene=''> | <StructureSection load='4lr6' size='340' side='right'caption='[[4lr6]], [[Resolution|resolution]] 1.29Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lr6]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4lr6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LR6 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.29Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1XA:3-METHYL-4-PHENYL-1,2-OXAZOL-5-AMINE'>1XA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lr6 OCA], [https://pdbe.org/4lr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lr6 RCSB], [https://www.ebi.ac.uk/pdbsum/4lr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lr6 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 20: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4lr6" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Albrecht | [[Category: Large Structures]] | ||
[[Category: Audia | [[Category: Albrecht B]] | ||
[[Category: Bellon | [[Category: Audia J]] | ||
[[Category: Bergeron | [[Category: Bellon S]] | ||
[[Category: Birudukota | [[Category: Bergeron L]] | ||
[[Category: Bryant | [[Category: Birudukota S]] | ||
[[Category: Cote | [[Category: Bryant B]] | ||
[[Category: Gehling | [[Category: Cote A]] | ||
[[Category: Harmange | [[Category: Gehling V]] | ||
[[Category: Hewitt | [[Category: Harmange J-C]] | ||
[[Category: Jayaram | [[Category: Hewitt M]] | ||
[[Category: Joshi | [[Category: Jayaram H]] | ||
[[Category: Leblanc | [[Category: Joshi S]] | ||
[[Category: Mertz | [[Category: Leblanc Y]] | ||
[[Category: Nandana | [[Category: Mertz J]] | ||
[[Category: Nasveschuk | [[Category: Nandana BS]] | ||
[[Category: Pardo | [[Category: Nasveschuk C]] | ||
[[Category: Poy | [[Category: Pardo E]] | ||
[[Category: Ravichandran | [[Category: Poy F]] | ||
[[Category: Sandy | [[Category: Ravichandran S]] | ||
[[Category: Sims | [[Category: Sandy P]] | ||
[[Category: Taylor | [[Category: Sims R]] | ||
[[Category: Vaswani | [[Category: Taylor A]] | ||
[[Category: Yellapuntala | [[Category: Vaswani R]] | ||
[[Category: Yellapuntala S]] | |||