4lm0: Difference between revisions

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 ==Crystal structure of PDE10A2 with fragment ZT448==
-<StructureSection load='4lm0' size='340' side='right' caption='[[4lm0]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
+<StructureSection load='4lm0' size='340' side='right'caption='[[4lm0]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4lm0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LM0 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4lm0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LM0 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5NI:5-NITROINDAZOLE'>5NI</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lkq|4lkq]], [[4llj|4llj]], [[4lll|4lll]], [[4llp|4llp]], [[4llx|4llx]], [[4lm1|4lm1]], [[4lm2|4lm2]], [[4lm3|4lm3]], [[4lm4|4lm4]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NI:5-NITROINDAZOLE'>5NI</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lm0 OCA], [https://pdbe.org/4lm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lm0 RCSB], [https://www.ebi.ac.uk/pdbsum/4lm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lm0 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lm0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lm0 RCSB], [http://www.ebi.ac.uk/pdbsum/4lm0 PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
+[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 18: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4lm0" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Phosphodiesterase|Phosphodiesterase]]
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Badger, J]]
+[[Category: Large Structures]]
-[[Category: Chie-Leon, B]]
+[[Category: Badger J]]
-[[Category: Logan, C]]
+[[Category: Chie-Leon B]]
-[[Category: Nienaber, V]]
+[[Category: Logan C]]
-[[Category: Sridhar, V]]
+[[Category: Nienaber V]]
-[[Category: Fragment screening]]
+[[Category: Sridhar V]]
-[[Category: Hydrolase]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]