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==Crystal structure of PDE10A2 with fragment ZT017==
==Crystal structure of PDE10A2 with fragment ZT017==
<StructureSection load='4lkq' size='340' side='right' caption='[[4lkq]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
<StructureSection load='4lkq' size='340' side='right'caption='[[4lkq]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lkq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LKQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lkq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LKQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1XM:4-AMINO-1,7-DIHYDRO-6H-PYRAZOLO[3,4-D]PYRIMIDINE-6-THIONE'>1XM</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4llj|4llj]], [[4lll|4lll]], [[4llp|4llp]], [[4llx|4llx]], [[4lm0|4lm0]], [[4lm1|4lm1]], [[4lm2|4lm2]], [[4lm3|4lm3]], [[4lm4|4lm4]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1XM:4-AMINO-1,7-DIHYDRO-6H-PYRAZOLO[3,4-D]PYRIMIDINE-6-THIONE'>1XM</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lkq OCA], [https://pdbe.org/4lkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lkq RCSB], [https://www.ebi.ac.uk/pdbsum/4lkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lkq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lkq OCA], [http://pdbe.org/4lkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lkq RCSB], [http://www.ebi.ac.uk/pdbsum/4lkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lkq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Badger, J]]
[[Category: Large Structures]]
[[Category: Chie-Leon, B]]
[[Category: Badger J]]
[[Category: Logan, C]]
[[Category: Chie-Leon B]]
[[Category: Nienaber, V]]
[[Category: Logan C]]
[[Category: Sridhar, V]]
[[Category: Nienaber V]]
[[Category: Fragment screening]]
[[Category: Sridhar V]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

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