4ljo: Difference between revisions
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==Structure of an active ligase (HOIP)/ubiquitin transfer complex== | ==Structure of an active ligase (HOIP)/ubiquitin transfer complex== | ||
<StructureSection load='4ljo' size='340' side='right' caption='[[4ljo]], [[Resolution|resolution]] 1.56Å' scene=''> | <StructureSection load='4ljo' size='340' side='right'caption='[[4ljo]], [[Resolution|resolution]] 1.56Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ljo]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4ljo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LJO FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.564Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ljo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ljo OCA], [https://pdbe.org/4ljo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ljo RCSB], [https://www.ebi.ac.uk/pdbsum/4ljo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ljo ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RNF31_HUMAN RNF31_HUMAN] E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.<ref>PMID:17006537</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref> <ref>PMID:22863777</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4ljo" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | ||
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Brown | [[Category: Large Structures]] | ||
[[Category: Christodoulou | [[Category: Brown NR]] | ||
[[Category: Howell | [[Category: Christodoulou E]] | ||
[[Category: | [[Category: Howell S]] | ||
[[Category: Morris-Davies | [[Category: Koliopoulos MG]] | ||
[[Category: Rana | [[Category: Morris-Davies AC]] | ||
[[Category: Rittinger | [[Category: Rana RR]] | ||
[[Category: Stieglitz | [[Category: Rittinger K]] | ||
[[Category: Stieglitz B]] | |||