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==Crystal structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase from Burkholderia thailandensis==
==Crystal structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase from Burkholderia thailandensis==
<StructureSection load='4lhr' size='340' side='right' caption='[[4lhr]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4lhr' size='340' side='right'caption='[[4lhr]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lhr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burta Burta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LHR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lhr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_thailandensis_E264 Burkholderia thailandensis E264]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LHR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BTH_I0767, dut ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=271848 BURTA])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lhr OCA], [https://pdbe.org/4lhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lhr RCSB], [https://www.ebi.ac.uk/pdbsum/4lhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lhr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lhr OCA], [http://pdbe.org/4lhr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lhr RCSB], [http://www.ebi.ac.uk/pdbsum/4lhr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lhr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DUT_BURTA DUT_BURTA]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity).  
[https://www.uniprot.org/uniprot/DUT_BURTA DUT_BURTA] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity).
 
==See Also==
*[[DUTPase 3D structures|DUTPase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Burta]]
[[Category: Burkholderia thailandensis E264]]
[[Category: DUTP diphosphatase]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Hydrolase]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Nucleotide metabolism]]
[[Category: Pyrimidine]]
[[Category: Ssgcid]]

Latest revision as of 19:19, 20 September 2023

Crystal structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase from Burkholderia thailandensisCrystal structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase from Burkholderia thailandensis

Structural highlights

4lhr is a 1 chain structure with sequence from Burkholderia thailandensis E264. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DUT_BURTA This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity).

See Also

4lhr, resolution 1.50Å

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