4lee: Difference between revisions
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==Structure of the Als3 adhesin from Candida albicans, residues 1-313 (mature sequence), triple mutant in the binding cavity: K59M, A116V, Y301F== | ==Structure of the Als3 adhesin from Candida albicans, residues 1-313 (mature sequence), triple mutant in the binding cavity: K59M, A116V, Y301F== | ||
<StructureSection load='4lee' size='340' side='right' caption='[[4lee]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='4lee' size='340' side='right'caption='[[4lee]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lee]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEE OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4lee]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LEE FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lee OCA], [https://pdbe.org/4lee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lee RCSB], [https://www.ebi.ac.uk/pdbsum/4lee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lee ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ALS3_CANAL ALS3_CANAL] Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.<ref>PMID:15128742</ref> <ref>PMID:15256583</ref> <ref>PMID:16839200</ref> <ref>PMID:17510860</ref> <ref>PMID:18635358</ref> <ref>PMID:22321066</ref> <ref>PMID:22429754</ref> <ref>PMID:22544909</ref> <ref>PMID:23630968</ref> <ref>PMID:24152214</ref> <ref>PMID:24736223</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Candida albicans]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Cota E]] | ||
[[Category: | [[Category: Garnett JA]] | ||
[[Category: | [[Category: Lin J]] | ||