4l4t: Difference between revisions

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-{{STRUCTURE_4l4t|  PDB=4l4t  |  SCENE=  }}
-===Structure of human MAIT TCR in complex with human MR1-6-FP===
-==Disease==
+==Structure of human MAIT TCR in complex with human MR1-6-FP==
-[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
+<StructureSection load='4l4t' size='340' side='right'caption='[[4l4t]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4l4t]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L4T FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6FP:2-AMINO-4-OXO-3,4-DIHYDROPTERIDINE-6-CARBALDEHYDE'>6FP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4t OCA], [https://pdbe.org/4l4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l4t RCSB], [https://www.ebi.ac.uk/pdbsum/4l4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l4t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes MR1 presenting vitamin B metabolites. Here we describe the structures of a human MAIT TCR in complex with human MR1 presenting a non-stimulatory ligand derived from folic acid and an agonist ligand derived from a riboflavin metabolite. For both vitamin B antigens, the MAIT TCR docks in a conserved manner above MR1, thus acting as an innate-like pattern recognition receptor. The invariant MAIT TCR alpha-chain usage is attributable to MR1-mediated interactions that prise open the MR1 cleft to allow contact with the vitamin B metabolite. Although the non-stimulatory antigen does not contact the MAIT TCR, the stimulatory antigen does. This results in a higher affinity of the MAIT TCR for a stimulatory antigen in comparison with a non-stimulatory antigen. We formally demonstrate a structural basis for MAIT TCR recognition of vitamin B metabolites, while illuminating how TCRs recognize microbial metabolic signatures.
-==Function==
+Recognition of vitamin B metabolites by mucosal-associated invariant T cells.,Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T, Corbett AJ, Liu L, Miles JJ, Meehan B, Reantragoon R, Sandoval-Romero ML, Sullivan LC, Brooks AG, Chen Z, Fairlie DP, McCluskey J, Rossjohn J Nat Commun. 2013;4:2142. doi: 10.1038/ncomms3142. PMID:23846752<ref>PMID:23846752</ref>
-[[http://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN]] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref>  [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
-==About this Structure==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[4l4t]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4T OCA].
+</div>
+<div class="pdbe-citations 4l4t" style="background-color:#fffaf0;"></div>
-==Reference==
+==See Also==
-<references group="xtra"/><references/>
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
+*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Beddoe, T.]]
+[[Category: Large Structures]]
-[[Category: Birkinshaw, R W.]]
+[[Category: Beddoe T]]
-[[Category: Brooks, A G.]]
+[[Category: Birkinshaw RW]]
-[[Category: Chen, Z.]]
+[[Category: Brooks AG]]
-[[Category: Corbett, A J.]]
+[[Category: Chen Z]]
-[[Category: Eckle, S B.G.]]
+[[Category: Corbett AJ]]
-[[Category: Fairlie, D P.]]
+[[Category: Eckle SBG]]
-[[Category: Kjer-Nielsen, L.]]
+[[Category: Fairlie DP]]
-[[Category: Liu, L.]]
+[[Category: Kjer-Nielsen L]]
-[[Category: McCluskey, J.]]
+[[Category: Le Nours J]]
-[[Category: Meehan, B.]]
+[[Category: Liu L]]
-[[Category: Miles, J J.]]
+[[Category: McCluskey J]]
-[[Category: Nours, J Le.]]
+[[Category: Meehan B]]
-[[Category: Patel, O.]]
+[[Category: Miles JJ]]
-[[Category: Reantragoon, R.]]
+[[Category: Patel O]]
-[[Category: Rossjohn, J.]]
+[[Category: Reantragoon R]]
-[[Category: Sandoval-Romero, M L.]]
+[[Category: Rossjohn J]]
-[[Category: Sullivan, L C.]]
+[[Category: Sandoval-Romero ML]]
-[[Category: Immune system]]
+[[Category: Sullivan LC]]
-[[Category: Mait tcr]]
-[[Category: Membrane protein-immune system complex]]
-[[Category: Mhc class i-related protein]]
-[[Category: Vitamin b metabolite]]