4kqw: Difference between revisions

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 ==The structure of the Slackia exigua KARI in complex with NADP==
-<StructureSection load='4kqw' size='340' side='right' caption='[[4kqw]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
+<StructureSection load='4kqw' size='340' side='right'caption='[[4kqw]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4kqw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Slackia_exigua_atcc_700122 Slackia exigua atcc 700122]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4kqw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Slackia_exigua_ATCC_700122 Slackia exigua ATCC 700122]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQW FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kqx|4kqx]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ilvC, HMPREF0762_00954 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=649764 Slackia exigua ATCC 700122])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kqw OCA], [https://pdbe.org/4kqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kqw RCSB], [https://www.ebi.ac.uk/pdbsum/4kqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kqw ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketol-acid_reductoisomerase Ketol-acid reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.86 1.1.1.86] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kqw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kqw RCSB], [http://www.ebi.ac.uk/pdbsum/4kqw PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/ILVC_SLAES ILVC_SLAES] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435]<ref>PMID:23776225</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4kqw" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ketol-acid reductoisomerase 3D structures|Ketol-acid reductoisomerase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Ketol-acid reductoisomerase]]
+[[Category: Large Structures]]
-[[Category: Slackia exigua atcc 700122]]
+[[Category: Slackia exigua ATCC 700122]]
-[[Category: Arnold, F H]]
+[[Category: Arnold FH]]
-[[Category: Brinkmann-Chen, S]]
+[[Category: Brinkmann-Chen S]]
-[[Category: Brustad, E M]]
+[[Category: Brustad EM]]
-[[Category: Cahn, J K.B]]
+[[Category: Cahn JKB]]
-[[Category: Flock, T]]
+[[Category: Flock T]]
-[[Category: Mcintosh, J A]]
+[[Category: Mcintosh JA]]
-[[Category: Meinhold, P]]
+[[Category: Meinhold P]]
-[[Category: Snow, C D]]
+[[Category: Snow CD]]
-[[Category: Zhang, L]]
+[[Category: Zhang L]]
-[[Category: Acetohydroxyacid isomeroreductase]]
-[[Category: Oxidoreductase]]
-[[Category: Rossmann fold]]