4juu: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of a putative hydroxyproline epimerase from xanthomonas campestris (TARGET EFI-506516) with bound phosphate and unknown ligand== | ==Crystal structure of a putative hydroxyproline epimerase from xanthomonas campestris (TARGET EFI-506516) with bound phosphate and unknown ligand== | ||
<StructureSection load='4juu' size='340' side='right' caption='[[4juu]], [[Resolution|resolution]] 1.75Å' scene=''> | <StructureSection load='4juu' size='340' side='right'caption='[[4juu]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4juu]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4juu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris_str._ATCC_33913 Xanthomonas campestris pv. campestris str. ATCC 33913]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JUU FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4juu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4juu OCA], [https://pdbe.org/4juu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4juu RCSB], [https://www.ebi.ac.uk/pdbsum/4juu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4juu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/4HYPE_XANCP 4HYPE_XANCP] Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Can also catalyze the epimerization of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp), albeit with 500-fold lower efficiency. Displays no proline racemase activity.<ref>PMID:24980702</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Xanthomonas campestris pv. campestris str. ATCC 33913]] | ||
[[Category: | [[Category: Al Obaidi NF]] | ||
[[Category: | [[Category: Almo SC]] | ||
[[Category: | [[Category: Bhosle R]] | ||
[[Category: | [[Category: Chowdhury S]] | ||
[[Category: | [[Category: Evans B]] | ||
[[Category: | [[Category: Gerlt JA]] | ||
[[Category: Hammonds | [[Category: Hammonds J]] | ||
[[Category: Hillerich | [[Category: Hillerich B]] | ||
[[Category: Imker | [[Category: Imker HJ]] | ||
[[Category: Love | [[Category: Love J]] | ||
[[Category: Morisco | [[Category: Morisco LL]] | ||
[[Category: | [[Category: Scott Glenn A]] | ||
[[Category: Seidel | [[Category: Seidel RD]] | ||
[[Category: Sojitra | [[Category: Sojitra S]] | ||
[[Category: Stead | [[Category: Stead M]] | ||
[[Category: Toro | [[Category: Toro R]] | ||
[[Category: Vetting | [[Category: Vetting MW]] | ||
[[Category: Washington | [[Category: Washington E]] | ||
[[Category: Wasserman | [[Category: Wasserman SR]] | ||
Latest revision as of 18:49, 20 September 2023
Crystal structure of a putative hydroxyproline epimerase from xanthomonas campestris (TARGET EFI-506516) with bound phosphate and unknown ligandCrystal structure of a putative hydroxyproline epimerase from xanthomonas campestris (TARGET EFI-506516) with bound phosphate and unknown ligand
Structural highlights
Function4HYPE_XANCP Catalyzes the epimerization of trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp). Is likely involved in a degradation pathway that converts t4LHyp to alpha-ketoglutarate. Can also catalyze the epimerization of trans-3-hydroxy-L-proline (t3LHyp) to cis-3-hydroxy-D-proline (c3DHyp), albeit with 500-fold lower efficiency. Displays no proline racemase activity.[1] References
|
| ||||||||||||||||||