4js9: Difference between revisions

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'''Unreleased structure'''


The entry 4js9 is ON HOLD  until Paper Publication
==Structural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme==
<StructureSection load='4js9' size='340' side='right'caption='[[4js9]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4js9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JS9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.784&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=MH0:MESOHEME'>MH0</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4js9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js9 OCA], [https://pdbe.org/4js9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4js9 RCSB], [https://www.ebi.ac.uk/pdbsum/4js9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4js9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>


Authors: Hannibal, L., Page, R.C., Bolisetty, K., Yu, Z., Misra, S., Stuehr, D.J.
==See Also==
 
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
Description: Structural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Bolisetty K]]
[[Category: Hannibal L]]
[[Category: Misra S]]
[[Category: Page RC]]
[[Category: Stuehr DJ]]
[[Category: Yu Z]]

Latest revision as of 18:47, 20 September 2023

Structural Characterization of Inducible Nitric Oxide Synthase Substituted With MesohemeStructural Characterization of Inducible Nitric Oxide Synthase Substituted With Mesoheme

Structural highlights

4js9 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.784Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NOS2_MOUSE Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.[1]

See Also

References

  1. ↑ Kim SF, Huri DA, Snyder SH. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005 Dec 23;310(5756):1966-70. PMID:16373578 doi:http://dx.doi.org/10.1126/science.1119407

4js9, resolution 2.78Å

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OCA
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