4jb3: Difference between revisions

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'''Unreleased structure'''


The entry 4jb3 is ON HOLD
==Crystal structure of BT_0970, a had family phosphatase from bacteroides thetaiotaomicron VPI-5482, TARGET EFI-501083, with bound sodium and glycerol, closed lid, ordered loop==
 
<StructureSection load='4jb3' size='340' side='right'caption='[[4jb3]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
Authors: Vetting, M.W., Toro, R., Bhosle, R., Kumar, P.R., Ghosh, A., Al Obaidi, N.F., Stead, M., Washington, E., Scott Glenn, A., Chowdhury, S., Evans, B., Hammonds, J., Hillerich, B., Love, J., Seidel, R.D., Imker, H.J., Dunaway-Mariano, D., Allen, K.N., Gerlt, J.A., Almo, S.C., Enzyme Function Initiative (EFI)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4jb3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JB3 FirstGlance]. <br>
Description: CRYSTAL STRUCTURE OF BT_0970, A HAD FAMILY PHOSPHATASE FROM BACTEROIDES THETAIOTAOMICRON VPI-5482, TARGET EFI-501083, WITH BOUND SODIUM AND GLYCEROL, CLOSED LID, ORDERED LOOP
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jb3 OCA], [https://pdbe.org/4jb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jb3 RCSB], [https://www.ebi.ac.uk/pdbsum/4jb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jb3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RIBX_BACTN RIBX_BACTN] Catalyzes the dephosphorylation of D-ribitol-5-phosphate and D-ribitol-1-phosphate. Is also able to dephosphorylate 5-amino-6-(5-phospho-D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway.<ref>PMID:25513739</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacteroides thetaiotaomicron VPI-5482]]
[[Category: Large Structures]]
[[Category: Al Obaidi NF]]
[[Category: Allen KN]]
[[Category: Almo SC]]
[[Category: Bhosle R]]
[[Category: Chowdhury S]]
[[Category: Dunaway-Mariano D]]
[[Category: Evans B]]
[[Category: Gerlt JA]]
[[Category: Ghosh A]]
[[Category: Hammonds J]]
[[Category: Hillerich B]]
[[Category: Imker HJ]]
[[Category: Kumar PR]]
[[Category: Love J]]
[[Category: Scott Glenn A]]
[[Category: Seidel RD]]
[[Category: Stead M]]
[[Category: Toro R]]
[[Category: Vetting MW]]
[[Category: Washington E]]

Latest revision as of 18:39, 20 September 2023

Crystal structure of BT_0970, a had family phosphatase from bacteroides thetaiotaomicron VPI-5482, TARGET EFI-501083, with bound sodium and glycerol, closed lid, ordered loopCrystal structure of BT_0970, a had family phosphatase from bacteroides thetaiotaomicron VPI-5482, TARGET EFI-501083, with bound sodium and glycerol, closed lid, ordered loop

Structural highlights

4jb3 is a 1 chain structure with sequence from Bacteroides thetaiotaomicron VPI-5482. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RIBX_BACTN Catalyzes the dephosphorylation of D-ribitol-5-phosphate and D-ribitol-1-phosphate. Is also able to dephosphorylate 5-amino-6-(5-phospho-D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway.[1]

References

  1. ↑ London N, Farelli JD, Brown SD, Liu C, Huang H, Korczynska M, Al-Obaidi NF, Babbitt PC, Almo SC, Allen KN, Shoichet BK. Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases. Biochemistry. 2015 Jan 20;54(2):528-37. doi: 10.1021/bi501140k. Epub 2015 Jan 5. PMID:25513739 doi:http://dx.doi.org/10.1021/bi501140k

4jb3, resolution 1.50Å

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