4iz6: Difference between revisions

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 ==Structure of EntE and EntB, an NRPS adenylation-PCP fusion protein with pseudo translational symmetry==
-<StructureSection load='4iz6' size='340' side='right' caption='[[4iz6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+<StructureSection load='4iz6' size='340' side='right'caption='[[4iz6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4iz6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IZ6 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4iz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IZ6 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1HZ:5-DEOXY-5-({[2-(2,3-DIHYDROXYPHENYL)ETHYL]SULFONYL}AMINO)ADENOSINE'>1HZ</scene>, <scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rg2|3rg2]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1HZ:5-DEOXY-5-({[2-(2,3-DIHYDROXYPHENYL)ETHYL]SULFONYL}AMINO)ADENOSINE'>1HZ</scene>, <scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0594, entE, entE and entB, JW0586, b0595, entB, entG, JW0587 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iz6 OCA], [https://pdbe.org/4iz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iz6 RCSB], [https://www.ebi.ac.uk/pdbsum/4iz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iz6 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iz6 OCA], [http://pdbe.org/4iz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iz6 RCSB], [http://www.ebi.ac.uk/pdbsum/4iz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iz6 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ENTE_ECOLI ENTE_ECOLI]] Activates the carboxylate group of 2,3-dihydroxy-benzoate (2,3-DHB), via ATP-dependent PPi exchange reactions, to the acyladenylate. Then, catalyzes the acylation of holo-EntB with 2,3-DHB adenylate, preparing that molecule for amide bond formation with L-serine.
+[https://www.uniprot.org/uniprot/ENTB_ECOLI ENTB_ECOLI] Required for production of 2,3-DHB. Also serves as an aryl carrier protein and plays a role in enterobactin assembly.[https://www.uniprot.org/uniprot/ENTE_ECOLI ENTE_ECOLI] Activates the carboxylate group of 2,3-dihydroxy-benzoate (2,3-DHB), via ATP-dependent PPi exchange reactions, to the acyladenylate. Then, catalyzes the acylation of holo-EntB with 2,3-DHB adenylate, preparing that molecule for amide bond formation with L-serine.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 24: / Line 23: @@
 __TOC__
 </StructureSection>
-[[Category: Bacillus coli migula 1895]]
+[[Category: Escherichia coli]]
-[[Category: Gulick, A M]]
+[[Category: Large Structures]]
-[[Category: Sundlov, J A]]
+[[Category: Gulick AM]]
-[[Category: 4'phosphopantetheinylation cofactor 4'pp]]
+[[Category: Sundlov JA]]
-[[Category: Acyl carrier protein]]
-[[Category: Adenylate-forming enzyme]]
-[[Category: Anl superfamily]]
-[[Category: Chimera protein]]
-[[Category: Fusion protein]]
-[[Category: Ligase]]
-[[Category: Non-ribosomal peptide synthetase]]
-[[Category: Nrps adenylation domains and acyl carrier protein domain]]
-[[Category: Pseudo-translational symmetry]]